Grapefruit extract

Details of Grapefruit Extract:

Specification: 98% Naringin

Appearance: Brown yellow powder

Active ingredient: Naringin

CAS No.: 10236-47-2

EINECS No.: 233-566-4

MF: C27H32O14

MW: 580.5346


Introduction of Grapefruit Extract:

Grapefruit Extract main ingredient is Naringin. Naringin a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo.

 

Ingestion of naringi and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metabolism, the consumption of citrus (esp. Grapefruit) and other juices with medications is contraindicated.

 

Naringin, followed by rutin, was the most potent flavonoid inhibitor of VEGF release, which causes angiogenesis, out of 21 flavonoids. When naringin powder is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated, it becomes a naringin dihydrochalcone, a compound roughly 300-1800 times sweeter than sugar at threshold concentrations.

 

Studies have shown that naringin interferes with enzymatic activity in the intestines and, thus, with the breakdown of certain drugs, resulting in higher blood levels of the drug. A number of drugs that are known to be affected by the naringin in grapefruit include calcium channel blockers, estrogen, sedatives, medications for high blood pressure, allergies, AIDS, and cholesterol-lowering drugs.


Main Function of Grapefruit Extract:

1.Component of the medicine which curse diabetes; 

2.Reduce Blood fat and liver fat, and also has the function of sedation;

3.For those pharmaceutical uses the better solubility of naringin in water is an advantage;

4.Have therapeutic action in influencing capillary permeability.


Application of Grapefruit Extract:

1.Applied in food field, various foods are use naringin as the materials;

2.Applied in cosmetic field, many sorts of naringin can nourish the skin;

3.Applied in pharmaceutical field, naringin is made into tablet or capsule, which is often used for eat less and coughing much sputum.

Title:

Summary:

                 

Grapefruit Extract main ingredient is Naringin. Naringin a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo.

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